The Formula 2 title favourite, who has signed a multi-year deal to race for Williams, has tested for Force India and Mercedes this season.
However, he had only driven on Williams’s simulator before convincing the team to give him his grand prix debut.
Williams has not confirmed its Abu Dhabi test line-up but chief technical officer Paddy Lowe said Russell would “almost certainly” be driving.
Mercedes junior Russell has been present at most grands prix this year with the Anglo-German team in his role as official reserve driver.
He spent the previous grand prix in Mexico with Williams and is embedded in the team again this weekend in Brazil.
Asked how well the 20-year-old has settled in at Williams, Lowe said: “Very well, yeah. He’s done the last two races with us.
“He is very enthusiastic, he is learning a lot already and I think it will allow him to hit the ground in better conditions than otherwise.
“We haven’t announced our line-up for the Abu Dhabi test, but almost certainly George will feature in that.
“Having done these two races he is in much better position to get the most out of his first sessions in the car.”