Romelu Lukaku returns to the starting line-up for Manchester United with Anthony Martial, who has scored seven times in 11 matches, missing out after picking up a hamstring injury during the 2-2 draw with Arsenal in midweek.
There are also starts for Phil Jones, Juan Mata and Ashley Young, who wears the captain’s armband. Paul Pogba, Fred, Luke Shaw and Marouane Fellaini are among the substitutes.
Manchester United: De Gea, Dalot, Jones, Smalling, Young, Matic,
Ander Herrera, Rashford, Mata, Lingard, Lukaku.
Rojo, Fred, Romero, Shaw, Fellaini, McTominay.
Some tinkering too from Fulham boss Claudio Ranieri, who makes five changes from the side that started the 1-1 draw versus Leicester on Wednesday.
In come captain Tom Cairney, Tim Ream, Andre Schurrle, Joe Bryan and Andre-Frank Zambo Anguissa.
Fulham: Sergio Rico, Odoi, Ream, Mawson, Bryan, Seri, Zambo, Schurrle, Cairney, Ryan Sessegnon, Mitrovic.
Substitutes: Bettinelli, Kebano, Johansen, Vietto, Christie, Cisse, Kamara.